Protein Details: Acid-sensing ion channel 1

Protein ID

ICDB_Pro_0864

Protein Name

Acid-sensing ion channel 1

Gene Name

ASIC1; ACCN2

Organism

Gallus gallus (Chicken)

Length

527 amino acids

AlphaFoldDB

AF-Q1XA76-F1-model_v4.pdb

Function

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions; but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

Sequence

MMDLKVDEEEVDSGQPVSIQAFASSSTLHGISHIFSYERLSLKRVVWALCFMGSLALLALVCTNRIQYYFLYPHVTKLDEVAATRLTFPAVTFCNLNEFRFSRVTKNDLYHAGELLALLNNRYEIPDTQTADEKQLEILQDKANFRNFKPKPFNMLEFYDRAGHDIREMLLSCFFRGEQCSPEDFKVVFTRYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPLIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWGDCKATTGDSEFYDTYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDNEYCVCEMPCNVTRYGKELSMVKIPSKASAKYLAKKYNKSEQYIGENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCRKNHKRNNTDKGVALSMDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC

PDB Structures

2QTS 3IJ4 3S3W 3S3X 4FZ0 4FZ1 4NTW 4NTX 4NTY 4NYK 5WKU 5WKV 5WKX 5WKY 6AVE 6CMC 6VTK 6VTL 6X9H 7LIE

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 72: "Important for channel gating"; SITE 80: "Important for channel desensitizing"; SITE 288: "Important for channel gating"

Disease

Location

DOI ID

10.1113/jphysiol.2005.087734; 10.1038/nature06163; 10.1038/nature08218; 10.1038/ncomms1917; 10.1038/nature11375; 10.1016/j.cell.2014.01.011

RefSeq

NP_001035557.1; XP_015155720.1; XP_015155721.1